Understanding how mitochondria transport calcium and other molecules for energy production
Molecular mechanisms of mitochondrial membrane transport systems in cellular energetics
This study is looking at how certain proteins in our cells help manage energy and calcium levels, which are really important for keeping our cells healthy, and it aims to understand how problems with these proteins might lead to diseases like heart and brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11055990 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind mitochondrial membrane transport systems, which are essential for energy production in cells. It focuses on how these systems regulate the movement of calcium and other metabolites, which is crucial for normal cellular function. By studying key transport proteins, such as the calcium uniporter and the mitochondrial pyruvate carrier, the research aims to uncover how their dysfunction contributes to various diseases, including cardiovascular and neurodegenerative disorders. The approach combines biochemical techniques and cellular models to gain insights into these critical processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders, cardiovascular diseases, or neurodegenerative conditions.
Not a fit: Patients with conditions unrelated to mitochondrial dysfunction or those not experiencing metabolic or cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating diseases linked to mitochondrial dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial transport mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Feng, Liang — Stanford University
- Study coordinator: Feng, Liang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.