Understanding how mitochondria transport calcium and other molecules for energy production
Official title: Molecular mechanisms of mitochondrial membrane transport systems in cellular energetics
Funded at Stanford University · NIH-11055990 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells help manage energy and calcium levels, which are really important for keeping our cells healthy, and it aims to understand how problems with these proteins might lead to diseases like heart and brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $860,698 |
| NIH project number | 5R35GM153424-02 |
| Project ID | NIH-11055990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders, cardiovascular diseases, or neurodegenerative conditions.
✕Less likely to help
Patients with conditions unrelated to mitochondrial dysfunction or those not experiencing metabolic or cardiovascular issues may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind mitochondrial membrane transport systems, which are essential for energy production in cells. It focuses on how these systems regulate the movement of calcium and other metabolites, which is crucial for normal cellular function. By studying key transport proteins, such as the calcium uniporter and the mitochondrial pyruvate carrier, the research aims to uncover how their dysfunction contributes to various diseases, including cardiovascular and neurodegenerative disorders. The approach combines biochemical techniques and cellular models to gain insights into these critical processes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating diseases linked to mitochondrial dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial transport mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
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Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Feng, Liang — Stanford University
- Study coordinator: Feng, Liang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.