Understanding how mitochondria take up iron to find new treatments for liver toxicity
Mechanisms of Mitochondrial Iron Uptake: New Therapeutic Targets in Hepatotoxicity
This study is looking at how mitochondria, the energy factories in our cells, take in iron and how this might lead to liver damage, especially from medications like acetaminophen, with the goal of finding new ways to help people with liver problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10817122 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which mitochondria absorb iron, focusing on how this process may contribute to liver toxicity, particularly from substances like acetaminophen. The study explores two potential pathways for iron uptake in mitochondria, one that is dependent on electrical charge and another that is not. By examining the interactions between specific proteins involved in iron transport, the research aims to uncover new therapeutic targets that could mitigate damage caused by excess iron in liver cells. Patients may benefit from insights gained in this research, leading to improved treatments for liver-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with liver conditions or those at risk of liver toxicity due to medications like acetaminophen.
Not a fit: Patients with liver conditions unrelated to iron metabolism or those not taking medications that affect liver function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect the liver from damage caused by iron overload.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial functions and their implications for liver health, suggesting that this approach may yield valuable insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Lemasters, John J — Medical University of South Carolina
- Study coordinator: Lemasters, John J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.