Understanding how mitochondria respond to energy dysfunction in the heart
Acylations: a novel pathway in the response to mitochondrial energy dysfunction
This study is looking at how heart cells respond when they don't have enough energy, using a special mouse model to see how these cells adapt and communicate during energy problems, which could help find new ways to treat heart diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11012887 on NIH RePORTER |
What this research studies
This research investigates the pathways that mitochondria activate in response to energy dysfunction, particularly in heart cells. By using a unique mouse model with induced mitochondrial energy impairment, the study aims to uncover how these cells communicate and adapt to energy crises. The focus is on understanding the role of specific protein modifications, known as acylations, that occur in response to mitochondrial dysfunction. This knowledge could lead to targeted strategies for treating degenerative diseases that affect high-energy tissues like the heart.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with cardiac conditions that may be linked to mitochondrial energy dysfunction.
Not a fit: Patients with non-cardiac diseases or those without mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cardiac diseases related to mitochondrial dysfunction.
How similar studies have performed: While the specific approach of studying acylations in this context is novel, similar research has shown promise in understanding mitochondrial dysfunction in other diseases.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Kwong, Jennifer Q. — Emory University
- Study coordinator: Kwong, Jennifer Q.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.