Understanding how mitochondria regulate insulin secretion in response to glucose.
Mitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11059185
This study is looking at how the cells in your pancreas that make insulin respond to sugar in your blood, and it hopes to find new ways to understand and treat diabetes better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11059185 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which pancreatic beta cells sense glucose and secrete insulin. It challenges the traditional view of how mitochondrial processes contribute to insulin release, proposing a new model that includes the role of specific metabolites in this process. By examining the interactions between mitochondrial function and insulin secretion, the study aims to uncover new insights into glucose metabolism and its effects on insulin release. Patients may benefit from a better understanding of diabetes and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes or those at risk of developing diabetes, particularly those with issues related to insulin secretion.
Not a fit: Patients who do not have diabetes or related metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetes by enhancing our understanding of insulin secretion mechanisms.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial function in insulin secretion, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIBBEY, RICHARD G — YALE UNIVERSITY
- Study coordinator: KIBBEY, RICHARD G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.