Understanding how mitochondria regulate energy supply in heart cells
Official title: Molecular mechanisms of mitochondrial metabolic regulation
Funded at Stanford University · NIH-10901736 · Data updated 2026-11-12
This study is looking into how heart cells take in a vital energy molecule called NAD+, which is important for keeping your heart healthy, and it hopes to find new ways to help people with heart failure by improving energy levels in those cells.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 16, 2024 |
| Project end | September 15, 2028 |
| Funding year | 2024 |
| Award (this year) | $41,856 |
| NIH project number | 1F30HL174099-01 |
| Project ID | NIH-10901736 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure or those at risk of developing heart-related conditions.
✕Less likely to help
Patients with heart failure caused by non-mitochondrial factors may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that control how mitochondria import NAD+, a crucial molecule for energy production in heart cells. By focusing on the transport process of NAD+ into the mitochondria, the study aims to uncover why heart cells often fail due to energy deficits. The approach involves advanced techniques to analyze the transport mechanisms and their implications for heart function. If successful, this research could lead to new therapeutic strategies for heart failure by restoring energy balance in cardiac cells.
Why it matters
Potential benefit: If successful, this research could provide new insights and treatments for heart failure, potentially improving patient outcomes.
How similar studies have gone: Other research has shown promise in targeting mitochondrial function to treat heart failure, indicating that this approach could be a significant advancement.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Krishnan, Aswini Ram — Stanford University
- Study coordinator: Krishnan, Aswini Ram
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.