Understanding how mitochondria regulate energy production and heat generation
Mechanisms of regulation of mitochondrial H+ leak and thermogenesis
This study is looking at how tiny parts of our cells called mitochondria help control energy production and heat generation, especially in fat cells that burn calories, to find new ways to treat age-related diseases and metabolic issues that can affect people with conditions related to energy balance.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11093335 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which mitochondria manage the balance between producing energy (ATP) and generating heat. It focuses on how certain proteins and chemical compounds can influence this balance, particularly in brown and beige fat cells, which are crucial for burning excess calories and preventing obesity. By exploring these processes, the research aims to uncover new therapeutic strategies for age-related diseases and metabolic disorders. Patients may benefit from insights that could lead to innovative treatments for conditions linked to mitochondrial dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing obesity or age-related metabolic disorders.
Not a fit: Patients with non-metabolic conditions or those not affected by mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for obesity and age-related diseases by enhancing mitochondrial function.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial thermogenesis and its implications for obesity treatment, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Bertholet, Ambre Marguerite Solange — University of California Los Angeles
- Study coordinator: Bertholet, Ambre Marguerite Solange
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.