Understanding how mitochondria produce energy and maintain their function
Molecular Mechanisms of Mitochondrial Biogenesis
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-10900755
This study looks at how tiny parts of our cells called mitochondria get the proteins they need to work properly, which is important for understanding how problems with these mitochondria can affect aging and diseases like Alzheimer's, so we can find ways to help improve their function and slow down disease progression.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-10900755 on ClinicalTrials.gov |
What this research studies
This research investigates the processes by which mitochondria, the energy-producing organelles in our cells, import proteins necessary for their function and maintenance. The study focuses on two key protein complexes, TOM and TIM, which facilitate the movement of these proteins across mitochondrial membranes. By exploring the mechanisms of mitochondrial biogenesis, the research aims to uncover how mitochondrial dysfunction contributes to aging and various diseases, including neurodegenerative disorders. Patients may benefit from insights gained into how to enhance mitochondrial function and potentially mitigate disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related conditions or neurodegenerative diseases linked to mitochondrial dysfunction.
Not a fit: Patients with conditions unrelated to mitochondrial function or those who are not experiencing age-related decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving mitochondrial function, which may help in treating age-related diseases and neurodegenerative disorders.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function and its implications for health, suggesting that this approach could yield valuable insights.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARK, EUNYONG — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: PARK, EUNYONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.