Understanding how mitochondria produce energy and maintain their function
Official title: Molecular Mechanisms of Mitochondrial Biogenesis
Funded at University of California Berkeley · NIH-10900755 · Data updated 2026-11-12
This study looks at how tiny parts of our cells called mitochondria get the proteins they need to work properly, which is important for understanding how problems with these mitochondria can affect aging and diseases like Alzheimer's, so we can find ways to help improve their function and slow down disease progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $318,683 |
| NIH project number | 5R01GM147628-02 |
| Project ID | NIH-10900755 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related conditions or neurodegenerative diseases linked to mitochondrial dysfunction.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or those who are not experiencing age-related decline may not benefit from this research.
What this research studies
This research investigates the processes by which mitochondria, the energy-producing organelles in our cells, import proteins necessary for their function and maintenance. The study focuses on two key protein complexes, TOM and TIM, which facilitate the movement of these proteins across mitochondrial membranes. By exploring the mechanisms of mitochondrial biogenesis, the research aims to uncover how mitochondrial dysfunction contributes to aging and various diseases, including neurodegenerative disorders. Patients may benefit from insights gained into how to enhance mitochondrial function and potentially mitigate disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving mitochondrial function, which may help in treating age-related diseases and neurodegenerative disorders.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function and its implications for health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Park, Eunyong — University of California Berkeley
- Study coordinator: Park, Eunyong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.