Understanding how mitochondria move in nerve cells
A control center for mitochondrial navigation in neurons
This study is looking at how tiny energy factories in brain cells, called mitochondria, move around and stay healthy, especially when it comes to diseases like Alzheimer's, to help find new ways to support brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10862729 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control the movement of mitochondria within neurons, which are crucial for cell health and function. It focuses on a protein complex that regulates mitochondrial transport and how various cellular signals, such as nutrient availability and calcium levels, influence this process. By using advanced genetic tools and cell biology techniques, the research aims to uncover how these signals interact to maintain mitochondrial integrity, particularly in the context of neurodegenerative diseases like Alzheimer's. The findings could provide insights into potential therapeutic targets for improving neuronal health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative conditions such as Alzheimer's disease or amyotrophic lateral sclerosis.
Not a fit: Patients with non-neurological conditions or those without mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodegenerative diseases by enhancing mitochondrial function in neurons.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dynamics in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Wang, Xinnan — Stanford University
- Study coordinator: Wang, Xinnan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.