Understanding how mitochondria maintain cellular health
Regulation of mitochondrial surveillance
['FUNDING_OTHER'] · RICE UNIVERSITY · NIH-11019795
This study is looking at how mitochondria, the tiny powerhouses in our cells, do more than just provide energy; they also play a big role in keeping our cells healthy, and it’s for anyone interested in understanding how problems with these mitochondria might lead to serious health issues like cancer or heart disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RICE UNIVERSITY (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11019795 on ClinicalTrials.gov |
What this research studies
This research investigates the critical roles of mitochondria beyond energy production, focusing on their involvement in various biochemical processes that affect cellular health. It explores how disruptions in mitochondrial function can lead to chronic diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions. The study examines the mechanisms of mitochondrial surveillance and homeostasis, particularly the ESRE pathway, which responds to stress and regulates gene expression to maintain mitochondrial integrity. By tracking mitochondrial health indicators, the research aims to uncover new insights into preventing cell death and promoting overall cellular resilience.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic diseases related to mitochondrial dysfunction, such as metabolic disorders, cardiovascular diseases, or neurodegenerative conditions.
Not a fit: Patients with acute, non-chronic conditions or those without any mitochondrial-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating chronic diseases linked to mitochondrial dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function and its implications for chronic diseases, indicating that this approach has potential for significant advancements.
Where this research is happening
HOUSTON, UNITED STATES
- RICE UNIVERSITY — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIRIENKO, NATASHA — RICE UNIVERSITY
- Study coordinator: KIRIENKO, NATASHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.