Understanding how mitochondria leak protons
Deciphering the mitochondrial proton leak
['FUNDING_OTHER'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-11249083
This study is looking at how energy production in our cells can be affected by a process called proton leak in mitochondria, which is important for people with conditions like diabetes, cancer, and aging, and it aims to find a better way to measure this process to help us understand it more clearly.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11249083 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms of proton leak in mitochondria, which are essential for energy production in our cells. By developing a new method to measure proton leak accurately, the study aims to differentiate between proton leak and proton slip, which can affect various health conditions. The approach involves using a pH-sensitive indicator in cells to assess mitochondrial function without the influence of metabolic activity. This could lead to a better understanding of mitochondrial roles in diseases like diabetes, cancer, and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders, aging-related conditions, or diseases linked to mitochondrial dysfunction.
Not a fit: Patients with conditions unrelated to mitochondrial function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve our understanding of mitochondrial dysfunction and lead to better treatments for metabolic and age-related diseases.
How similar studies have performed: While the study of mitochondrial function is well-established, the specific approach of measuring proton leak and slip is novel and has not been extensively tested.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, HUILIANG — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: ZHANG, HUILIANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.