Understanding how mitochondria influence muscle signaling for healthy aging.
Official title: Mechanism of mitochondria-induced myokine activation and implications for healthy aging.
Funded at Upstate Medical University · NIH-10902778 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called mitochondria help muscles release helpful signals during exercise, which could lead to new ways to improve health for people with conditions like obesity and diabetes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | June 25, 2024 |
| Project end | June 24, 2025 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 1F31AG087692-01 |
| Project ID | NIH-10902778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing obesity, type 2 diabetes, or cardiovascular issues, particularly those interested in the effects of exercise on health.
✕Less likely to help
Patients who are not affected by obesity or related metabolic conditions may not receive direct benefits from this research.
What this research studies
This research investigates the role of mitochondria in activating myokines, which are signaling molecules released from muscles during exercise. By studying a new mouse model, the researchers aim to uncover how mitochondrial stress affects myokine expression and its implications for metabolic health and heart function. The approach involves examining specific transcription factors that may mediate this signaling process, potentially leading to new therapeutic targets for conditions like obesity and diabetes. Patients may benefit from insights into how exercise can improve health outcomes through these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting metabolic health and preventing age-related diseases.
How similar studies have gone: Previous research has shown promising results in understanding myokine signaling and its effects on health, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Mauro, Joseph V. — Upstate Medical University
- Study coordinator: Mauro, Joseph V.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.