Understanding how mitochondria influence muscle signaling for healthy aging.
Mechanism of mitochondria-induced myokine activation and implications for healthy aging.
This study is looking at how tiny parts of our cells called mitochondria help muscles release helpful signals during exercise, which could lead to new ways to improve health for people with conditions like obesity and diabetes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10902778 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondria in activating myokines, which are signaling molecules released from muscles during exercise. By studying a new mouse model, the researchers aim to uncover how mitochondrial stress affects myokine expression and its implications for metabolic health and heart function. The approach involves examining specific transcription factors that may mediate this signaling process, potentially leading to new therapeutic targets for conditions like obesity and diabetes. Patients may benefit from insights into how exercise can improve health outcomes through these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing obesity, type 2 diabetes, or cardiovascular issues, particularly those interested in the effects of exercise on health.
Not a fit: Patients who are not affected by obesity or related metabolic conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting metabolic health and preventing age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding myokine signaling and its effects on health, suggesting that this approach may yield valuable insights.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Mauro, Joseph V. — Upstate Medical University
- Study coordinator: Mauro, Joseph V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.