Understanding how mitochondria help bone marrow heal after stem cell transplants
Official title: Mitochondria mediated intercellular metabolic coupling in bone marrow regeneration
Funded at Dana-Farber Cancer Inst · NIH-10976272 · Data updated 2026-11-12
This study is looking at how healthy stem cells can help damaged bone marrow recover after a transplant by sharing their energy-producing parts, called mitochondria, which could lead to better treatment and recovery for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $150,000 |
| NIH project number | 2R01DK124115-04A1 |
| Project ID | NIH-10976272 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing hematopoietic stem cell transplantation or those with conditions affecting their bone marrow.
✕Less likely to help
Patients with stable bone marrow function or those not requiring stem cell transplantation may not benefit from this research.
What this research studies
This research investigates the role of mitochondria in the recovery of bone marrow after hematopoietic stem cell transplantation. It focuses on how healthy stem cells can transfer functional mitochondria to damaged bone marrow cells, which may enhance their recovery and improve overall treatment outcomes. The study aims to uncover the mechanisms behind this mitochondrial transfer and its impact on bone marrow regeneration, potentially leading to better transplantation protocols. Patients may benefit from insights that could optimize their treatment and recovery processes.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies for patients undergoing stem cell transplants, enhancing their overall treatment outcomes.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dynamics in stem cell therapies, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Cancelas, Jose a. — Dana-Farber Cancer Inst
- Study coordinator: Cancelas, Jose a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.