Understanding how mitochondria function and change in cells
Structure, Turnover and Safeguard of Mitochondria
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-10992181
This study looks at how tiny powerhouses in our cells, called mitochondria, change and work, especially as we age and face brain-related diseases, to find ways to help improve health when these powerhouses aren't functioning well.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10992181 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamic nature of mitochondria, which are crucial for cell health and survival. It focuses on how mitochondria grow, divide, fuse, and degrade, particularly in the context of age-related neurodegenerative diseases. The study aims to uncover the molecular mechanisms behind these processes, including the roles of specific proteins that regulate mitochondrial behavior. By understanding these mechanisms, the research seeks to identify potential interventions for diseases linked to mitochondrial dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing symptoms of neurodegenerative diseases.
Not a fit: Patients with neurodegenerative diseases not related to mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for age-related neurodegenerative diseases by targeting mitochondrial dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dynamics and their implications for various diseases, indicating that this approach has potential for success.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SESAKI, HIROMI — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SESAKI, HIROMI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated neurodegenerative disease, age associated neurodegenerative disorder, age dependent neurodegenerative disease, age dependent neurodegenerative disorder, age-driven neurodegenerative disorders