Understanding how mitochondria divide and their role in diseases
Defining Molecular Interactions that Drive Mitochondrial Fission
This study is looking at how a protein called Drp1 helps control the division of mitochondria, which are the powerhouses of our cells, and how problems with this protein might lead to diseases like cancer and neurodegeneration, with the hope that the findings could help develop new treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11009587 on NIH RePORTER |
What this research studies
This research investigates the molecular interactions that control the division of mitochondria, which are essential for energy production and cell health. By studying a specific protein called Drp1, the research aims to uncover how its dysregulation can lead to cellular damage and contribute to diseases like cancer and neurodegeneration. The approach combines advanced imaging techniques and functional cell experiments to provide a detailed understanding of mitochondrial dynamics. Patients may benefit from insights gained that could lead to new therapeutic strategies for degenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include children and young adults with degenerative diseases such as neurodegeneration or cancer.
Not a fit: Patients with conditions unrelated to mitochondrial dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to mitochondrial dysfunction.
How similar studies have performed: Previous research has shown promising results in targeting mitochondrial dynamics for therapeutic purposes, indicating potential for success in this area.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Mears, Jason — Case Western Reserve University
- Study coordinator: Mears, Jason
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.