Understanding how mitochondria combine inside cells
Determining the mechanism of mitochondrial outer membrane fusion
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11072001
This research explores how tiny powerhouses in our cells, called mitochondria, join together, which is important for keeping them healthy and preventing age-related diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11072001 on ClinicalTrials.gov |
What this research studies
Our cells contain mitochondria, which are like tiny power plants that create energy. The shape of these mitochondria, and their ability to fuse or combine, is crucial for how well they work and how our cells respond to stress and aging. When mitochondria don't fuse properly, it can lead to problems like neurodegeneration and other conditions that affect older adults. This project looks closely at specific proteins called mitofusins, which are responsible for helping mitochondria connect and merge. By understanding how these proteins work, we hope to learn more about how to keep mitochondria healthy.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals with neurodegenerative diseases, age-related conditions, peripheral neuropathy, optic atrophy, myopathy, or ataxia, as these conditions are associated with compromised mitochondrial function.
Not a fit: Patients without conditions related to mitochondrial dysfunction or those seeking immediate clinical interventions may not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of diseases linked to mitochondrial dysfunction, potentially paving the way for new treatments for neurodegenerative and age-related conditions.
How similar studies have performed: This project addresses gaps in current knowledge regarding the molecular details of mitochondrial fusion, indicating it is exploring novel aspects of this biological process.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOPPINS, SUZANNE C — UNIVERSITY OF WASHINGTON
- Study coordinator: HOPPINS, SUZANNE C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.