Understanding how mitochondria change and function in cells
Official title: Modeling and Analysis of the Spatio-Temporal Dynamics of the Mitochondrial Network
Funded at University of California, San Diego · NIH-11089506 · Data updated 2026-11-12
This study is looking at how the tiny energy factories in our cells, called mitochondria, change shape and work differently when we're stressed or sick, to help us understand how problems with them might lead to diseases like Alzheimer's or cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $295,999 |
| NIH project number | 5R01GM148765-03 |
| Project ID | NIH-11089506 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodegenerative diseases, particularly those related to mitochondrial dysfunction, such as Alzheimer's disease.
✕Less likely to help
Patients with conditions unrelated to mitochondrial dysfunction or those who do not have neurodegenerative diseases may not benefit from this research.
What this research studies
This research investigates the dynamic behavior of mitochondria, the energy-producing structures in our cells, which can change shape and function in response to stress or disease. Using advanced imaging techniques, the study aims to create a detailed model of how these changes occur over time and space within cells. By analyzing the mitochondrial network's behavior, the research seeks to uncover fundamental principles that could explain how mitochondrial dysfunction contributes to various diseases, including neurodegenerative disorders and cancer.
Why it matters
Potential benefit: If successful, this research could lead to new insights into mitochondrial diseases and potential therapeutic strategies for conditions like Alzheimer's and other neurodegenerative diseases.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques to study cellular dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Schoeneberg, Johannes — University of California, San Diego
- Study coordinator: Schoeneberg, Johannes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.