Understanding how mitochondria are transported in nerve cells
Mechanism and function of retrograde mitochondrial transport in axons
This study is looking at how tiny energy-producing parts of nerve cells, called mitochondria, move around and stay healthy, especially in people with neurodegenerative diseases like Alzheimer's, to find ways to help improve their function and support brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11014393 on NIH RePORTER |
What this research studies
This research investigates the mechanisms and functions of mitochondrial transport within axons, which are the long projections of nerve cells. Mitochondria play a crucial role in energy production and cellular health, especially in neurons that require high energy levels. The study aims to explore how these organelles are moved and maintained in nerve cells, particularly in the context of neurodegenerative diseases like Alzheimer's. By examining the transport processes and their implications for neuronal health, the research seeks to uncover potential therapeutic targets for improving mitochondrial function in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing neurodegenerative conditions.
Not a fit: Patients with non-neurodegenerative conditions or those without any cognitive impairments may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing Alzheimer's disease by improving mitochondrial function in neurons.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Drerup, Catherine M — University of Wisconsin-Madison
- Study coordinator: Drerup, Catherine M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.