Understanding how mitochondria are positioned in mature neurons.
Official title: The role and regulation of mitochondrial localization in mature neurons.
Funded at University of Florida · NIH-10994168 · Data updated 2026-11-12
This study looks at how brain cells move tiny energy factories called mitochondria to keep them healthy, especially as we age or after an injury, and it hopes to find ways to help prevent or lessen problems like Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | April 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $338,617 |
| NIH project number | 5R01AG081270-03 |
| Project ID | NIH-10994168 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old, particularly those experiencing age-related neurological changes or conditions such as Alzheimer's disease.
✕Less likely to help
Patients with neurological conditions unrelated to mitochondrial dysfunction or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how neurons manage the location of mitochondria, which are crucial for energy supply and overall cell health. It focuses on the signaling mechanisms that control mitochondrial positioning in response to various stimuli, particularly in the context of aging and injury. By studying these processes, the research aims to uncover how proper mitochondrial localization can support neuronal function and potentially prevent or mitigate neurological disorders like Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing neurodegenerative diseases by improving mitochondrial function in neurons.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dynamics in neurons, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Han, Sung Min — University of Florida
- Study coordinator: Han, Sung Min
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.