Understanding how mitochondria and the endoplasmic reticulum interact with amyloid in Alzheimer's disease
Official title: Interactions between Mitochondria, ER, and Amyloid
Funded at University of Kansas Medical Center · NIH-10930832 · Data updated 2026-11-12
This study is looking at how certain parts of our cells work together in Alzheimer's disease, specifically focusing on a protein that can lead to harmful buildup in the brain, with the hope of finding new ways to treat the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | August 6, 2023 |
| Project end | August 5, 2028 |
| Funding year | 2024 |
| Award (this year) | $37,827 |
| NIH project number | 5F31AG084298-02 |
| Project ID | NIH-10930832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the relationship between mitochondria, the endoplasmic reticulum (ER), and amyloid beta (Aβ) in Alzheimer's disease (AD). It aims to understand how the localization of amyloid precursor protein (APP) at these cellular structures affects the production of Aβ, which is a key factor in AD pathology. The study will explore the role of mitochondrial-associated membranes (MAMs) in this process and how their function may influence APP processing. By examining these interactions, the research seeks to uncover mechanisms that could lead to new therapeutic strategies for AD.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for Alzheimer's disease, improving outcomes for patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of mitochondrial and ER interactions in Alzheimer's disease, indicating that this approach has potential for further exploration.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Strope, Taylor a. — University of Kansas Medical Center
- Study coordinator: Strope, Taylor a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.