Understanding how mitochondria and peroxisomes influence cell behavior and identity
Molecular Principles Governing Mitochondrial and Peroxisomal Remodeling as Drivers of Cell Fate and Identity
This study looks at how tiny parts of our cells, called mitochondria and peroxisomes, work together to keep our cells healthy, especially in relation to brain development, and it hopes to help people understand how problems with these parts can lead to health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-10765221 on NIH RePORTER |
What this research studies
This research investigates the roles of mitochondria and peroxisomes in regulating cell fate and identity, focusing on a protein called MCL-1 that helps control these organelles' shapes and functions. By studying how these organelles interact and change, the research aims to uncover mechanisms that are crucial for maintaining healthy cell function, particularly in the context of neurodevelopmental diseases. Patients may benefit from insights gained about how disruptions in these processes can lead to various health conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurodevelopmental disorders or those at risk due to genetic factors affecting mitochondrial and peroxisomal function.
Not a fit: Patients with conditions unrelated to mitochondrial or peroxisomal dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodevelopmental diseases linked to mitochondrial and peroxisomal dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dynamics, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Gama, Vivian — Vanderbilt University
- Study coordinator: Gama, Vivian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.