Understanding how mitochondria and DNA contribute to aging
Roles of mitochondrial dynamics and mtDNA in senescence
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11059058
This study is looking at how tiny parts of our cells called mitochondria and their DNA affect aging, especially how they help our bodies get rid of damaged cells, which can lead to age-related health issues. It's for anyone interested in understanding more about what happens in our cells as we get older.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11059058 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of mitochondria and nuclear DNA in cellular aging, particularly focusing on how these components trigger the senescence program, which is a natural defense mechanism that removes damaged cells. By analyzing the behavior of mitochondria and their DNA in aging cells, the study aims to uncover the mechanisms behind the accumulation of senescent cells that contribute to aging and age-related diseases. The research employs gene expression analysis and pharmacological interventions to explore how changes in mitochondrial DNA affect cellular functions and inflammation associated with aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be experiencing age-related health issues.
Not a fit: Patients under the age of 65 or those without age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for delaying aging and improving health in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of cellular mechanisms in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAO, TSO-PANG — DUKE UNIVERSITY
- Study coordinator: YAO, TSO-PANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.