Understanding how mitochondria affect Tau pathology and inflammation in Alzheimer's disease
Mitochondria modulate Tau pathology and neuroinflammation
This study is looking at how problems with tiny energy factories in our cells and a protein called Tau might contribute to Alzheimer's disease, and it aims to see if targeting a specific protein could help improve memory and reduce damage in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10868535 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial dysfunction and the protein Tau in the development of Alzheimer's disease. It focuses on how abnormal Tau accumulation leads to mitochondrial damage, inflammation, and memory loss. The study aims to explore the mechanisms behind Tau pathology and how targeting a specific protein, Cyclophilin D, could help restore mitochondrial function and reduce neuroinflammation. By using animal models, the researchers will assess the potential benefits of blocking Cyclophilin D to improve cognitive function and reduce Tau-related damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease by targeting mitochondrial dysfunction and Tau pathology.
How similar studies have performed: Previous research has shown promising results in targeting mitochondrial dysfunction in Alzheimer's models, suggesting potential for success in this approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Yan, Shirley Shidu — Columbia University Health Sciences
- Study coordinator: Yan, Shirley Shidu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.