Understanding how mitochondria affect sperm cell development
Mitochondrial dynamics in spermatogonial differentiation
['FUNDING_R01'] · MICHIGAN STATE UNIVERSITY · NIH-10895967
This study looks at how the tiny powerhouses in our cells, called mitochondria, help sperm-producing cells develop and stay healthy, with the hope of finding ways to improve fertility for those trying to conceive.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHIGAN STATE UNIVERSITY (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-10895967 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondria in the differentiation of spermatogonial stem cells, which are crucial for sperm production. It focuses on how mitochondrial dynamics, including their fusion and fission, influence cellular functions and the balance between energy production and cellular health. By examining the relationship between mitochondrial activity and the development of sperm cells, the research aims to uncover mechanisms that could improve fertility outcomes. Patients may benefit from insights into how mitochondrial health impacts their ability to conceive.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old who are experiencing challenges with fertility or sperm production.
Not a fit: Patients who are not experiencing fertility issues or are over the age of 21 may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving fertility in individuals facing difficulties conceiving.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial roles in cell differentiation, suggesting that this approach could yield valuable insights.
Where this research is happening
EAST LANSING, UNITED STATES
- MICHIGAN STATE UNIVERSITY — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, YUAN — MICHIGAN STATE UNIVERSITY
- Study coordinator: WANG, YUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.