Understanding how mitochondria affect insulin secretion in type 2 diabetes
Official title: Novel components of mitochondrial regulation of insulin secretion in type 2 diabetes
Funded at Buck Institute for Research on Aging · NIH-10997343 · Data updated 2026-11-12
This study is looking at how the energy factories in your cells, called mitochondria, affect the way your body releases insulin, which is important for controlling blood sugar, especially in people with type 2 diabetes, to help find better treatments for managing the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $670,313 |
| NIH project number | 5R01DK135807-02 |
| Project ID | NIH-10997343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 2 diabetes who are experiencing challenges in insulin secretion.
✕Less likely to help
Patients without type 2 diabetes or those with other forms of diabetes may not benefit from this research.
What this research studies
This research investigates the role of mitochondrial function in insulin secretion from beta cells, which are crucial for regulating blood sugar levels. It aims to identify the metabolic changes that occur in beta cells of individuals with type 2 diabetes, particularly how these changes impair their ability to respond to glucose. By using human islet cells and advanced techniques like CRISPR, the study seeks to uncover the mechanisms behind these dysfunctions and explore potential therapeutic targets. Patients may benefit from insights that could lead to more effective treatments for managing type 2 diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore normal insulin secretion in patients with type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function in diabetes, but this specific approach is novel and aims to provide deeper insights.
Where this research is happening
-
Buck Institute for Research on Aging
Novato, United States Active
Researchers
- Principal investigator: Gerencser, Akos a — Buck Institute for Research on Aging
- Study coordinator: Gerencser, Akos a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.