Understanding how mitochondria affect immune responses in bowel diseases
Official title: Mitochondrial Mechanisms Promoting Innate and Intestinal Immunity
Funded at Yale University · NIH-11010397 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called mitochondria affect the immune system in people with inflammatory bowel disease (IBD), especially how they help immune cells respond to germs, and it aims to find out if problems with these mitochondria make IBD worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | March 15, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $505,540 |
| NIH project number | 5R01DK135587-03 |
| Project ID | NIH-11010397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including conditions like colitis.
✕Less likely to help
Patients with non-inflammatory bowel conditions or those without any gastrointestinal issues may not benefit from this research.
What this research studies
This research investigates the role of mitochondrial mechanisms in regulating immune responses related to inflammatory bowel disease (IBD). It focuses on how mitochondria interact with immune cells, particularly macrophages, to balance cytokine and antimicrobial responses when encountering microbes. By examining the genetic factors associated with IBD, the study aims to uncover how mitochondrial dysfunction contributes to the disease and its symptoms. The approach includes analyzing metabolic pathways and the release of mitochondrial DNA in response to microbial stimulation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing inflammatory bowel disease and improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial roles in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Abraham, Clara — Yale University
- Study coordinator: Abraham, Clara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.