Understanding how mitochondria affect brain inflammation in epilepsy
Mitochondrial Mechanisms of Astrogliosis in Epilesy
This project explores how tiny powerhouses in brain cells, called mitochondria, might cause inflammation that leads to epilepsy.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11137692 on NIH RePORTER |
What this research studies
We are looking into whether problems with mitochondria inside brain cells can trigger inflammation, a process called astrogliosis, which is linked to epilepsy. Our team will use advanced imaging and special mouse models to see if these mitochondrial issues lead to lasting brain inflammation and seizures. The goal is to uncover new ways that brain cells communicate to cause inflammation, potentially leading to new treatments.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals living with acquired epilepsy, as it seeks to understand underlying causes.
Not a fit: Patients whose epilepsy is not related to brain inflammation or mitochondrial dysfunction may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for epilepsy that target specific metabolic processes in the brain.
How similar studies have performed: While neuroinflammation is a known target for epilepsy, the specific role of mitochondrial reactive oxygen species in activating astrogliosis in this non-cell autonomous way is a novel area of exploration.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Patel, Manisha N — University of Colorado Denver
- Study coordinator: Patel, Manisha N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.