Understanding how mitochondria affect brain cells that regulate inhibition
Mitochondrial Metabolic Regulation of GABAergic Interneurons
['FUNDING_CAREER'] · LURIE CHILDREN'S HOSPITAL OF CHICAGO · NIH-10985842
This study is looking at how tiny parts of our cells called mitochondria affect special brain cells that help keep our brain activity balanced, and it aims to find out how problems with these mitochondria might lead to issues in kids with certain brain-related conditions.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LURIE CHILDREN'S HOSPITAL OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10985842 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondria in GABAergic interneurons, which are crucial for balancing brain activity. By studying both human-derived cells and mice, the researchers aim to understand how mitochondrial dysfunction impacts these neurons' survival and function. The approach includes manipulating mitochondrial activity in lab-grown cells and observing the effects in animal models. This could lead to insights into potential treatments for primary mitochondrial diseases that affect neurological function in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with primary mitochondrial diseases and exhibit neurological symptoms.
Not a fit: Patients with non-mitochondrial related neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological symptoms associated with primary mitochondrial diseases in children.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function in neurons, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- LURIE CHILDREN'S HOSPITAL OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MITHAL, DIVAKAR SINGH — LURIE CHILDREN'S HOSPITAL OF CHICAGO
- Study coordinator: MITHAL, DIVAKAR SINGH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.