Understanding how mislocalized membrane proteins affect neurodegenerative diseases
Quality control of mislocalized membrane proteins
['FUNDING_R01'] · HARVARD MEDICAL SCHOOL · NIH-11057597
This study is looking at how certain proteins in our cells can go to the wrong place and cause problems, which might help us understand diseases like Alzheimer's and ALS better, with the hope of finding new ways to treat them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11057597 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the quality control of membrane proteins, which are crucial for the proper functioning of cells. It focuses on how mislocalized proteins can lead to dysfunction in cellular compartments, contributing to neurodegenerative diseases like Alzheimer's and ALS. By studying specific proteins and their localization, the research aims to uncover insights that could lead to new treatment strategies. Patients may benefit from a better understanding of these diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative disorders such as Alzheimer's disease or ALS.
Not a fit: Patients with non-neurodegenerative conditions or those without any cognitive or motor impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the management of neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding membrane protein quality control in relation to neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAO, SICHEN — HARVARD MEDICAL SCHOOL
- Study coordinator: SHAO, SICHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Amyotrophic Lateral Sclerosis Motor Neuron Disease