Understanding how misfolded proteins are processed in Alzheimer's disease
The Mechanistic Basis of Selective ER-Export of Misfolded Secretory Pathway Proteins
This study is looking at how our cells deal with misfolded proteins, which can build up and contribute to Alzheimer's disease, and it hopes to find new ways to help improve the health of these proteins, potentially benefiting patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10673895 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind how misfolded proteins are handled in the secretory pathway, particularly in relation to Alzheimer's disease. It focuses on a newly discovered pathway called RESET, which selectively exports misfolded proteins from the endoplasmic reticulum to the Golgi apparatus for degradation. By studying this process, the research aims to uncover how the accumulation of misfolded proteins contributes to Alzheimer's and other related diseases. Patients may benefit from insights gained into potential therapeutic targets for improving protein quality control in their cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to protein misfolding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the management of Alzheimer's disease by enhancing the clearance of misfolded proteins.
How similar studies have performed: Other research has shown promise in targeting protein misfolding pathways, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Satpute-Krishnan, Prasanna — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Satpute-Krishnan, Prasanna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.