Understanding how misfolded huntingtin protein contributes to Huntington's disease and finding ways to inhibit it
Molecular Mechanism of Huntingtin Misfolding and its Inhibition by Designed and Cellular Proteins
This study is looking at how a protein related to Huntington's disease gets messed up and clumps together, with the hope of finding new ways to help people living with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10894743 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind the misfolding of the huntingtin protein, which is linked to Huntington's disease. The team aims to characterize the different forms that this protein can take as it aggregates, which is a key factor in the disease's progression. By using advanced techniques like cryo-electron microscopy and various biochemical assays, they will explore how these misfolded proteins can be recognized and potentially inhibited by cellular chaperones. The ultimate goal is to gain insights that could lead to new therapeutic strategies for patients affected by Huntington's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Huntington's disease or those at risk due to family history.
Not a fit: Patients with other neurodegenerative disorders unrelated to Huntington's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Huntington's disease.
How similar studies have performed: Previous research has shown promise in understanding protein misfolding in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Langen, Ralf — University of Southern California
- Study coordinator: Langen, Ralf
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.