Understanding how mis-splicing affects cancer characteristics
Official title: Dissecting the contribution of mis-splicing in cancer phenotypes through multi-omic single-cell approaches
Funded at Weill Medical Coll of Cornell Univ · NIH-11035949 · Data updated 2026-11-12
This study is looking at how mistakes in the way RNA is processed can affect cancer cells and their behavior, with the hope of finding new ways to improve treatments for patients with cancers like myelodysplastic syndromes and ovarian cancer.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $122,032 |
| NIH project number | 1K99CA297005-01 |
| Project ID | NIH-11035949 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with myelodysplastic syndromes or high-grade serous ovarian cancer.
✕Less likely to help
Patients with cancers not related to splicing errors or those without the specific mutations being studied may not benefit from this research.
What this research studies
This research investigates how errors in RNA splicing contribute to the diversity of cancer cells and their behaviors. By examining specific mutations in splicing factors across different cancer types, including myelodysplastic syndromes and ovarian cancer, the study aims to uncover how these splicing errors influence tumor development and immune responses. The research employs advanced techniques like single-cell sequencing to analyze individual cancer cells, providing insights into their unique characteristics and potential vulnerabilities. Ultimately, the goal is to identify new targets for immunotherapy that could improve treatment outcomes for patients.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy strategies that specifically target cancer cells based on their unique splicing profiles.
How similar studies have gone: Similar research has shown promise in understanding the role of splicing in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Cortes Lopez, Mariela — Weill Medical Coll of Cornell Univ
- Study coordinator: Cortes Lopez, Mariela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.