Understanding how mineralocorticoid receptors regulate gene activity
Official title: Multifaceted Regulation of Mineralocorticoid Receptor Transcriptional Activities
Funded at Emory University · NIH-10941132 · Data updated 2026-11-12
This study is looking at how certain receptors in your body help control important functions like fluid balance and inflammation, which could lead to new treatments for heart and kidney problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $388,228 |
| NIH project number | 1R35GM155032-01 |
| Project ID | NIH-10941132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from cardiovascular or renal diseases, particularly those with conditions related to fluid and electrolyte imbalances.
✕Less likely to help
Patients with conditions unrelated to mineralocorticoid receptor activity or those not experiencing cardiovascular or renal issues may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms by which mineralocorticoid receptors (MR) control gene expression in various tissues, including the heart, brain, and adipose tissue. By focusing on the interactions between different domains of the receptor, the study aims to uncover how these receptors contribute to important biological processes such as fluid balance and inflammation. The research employs advanced techniques to analyze the structure and function of these receptors, which could lead to new therapeutic strategies for conditions like cardiovascular and renal diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cardiovascular and renal diseases by enhancing our understanding of mineralocorticoid receptor function.
How similar studies have gone: Previous research has shown promise in targeting mineralocorticoid receptors for therapeutic purposes, indicating that this approach has potential for success.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Liu, Xu — Emory University
- Study coordinator: Liu, Xu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.