Understanding how middle age affects the risk of Alzheimer's disease and related dementias.
Trajectories of Cognition in Middle Age: Implications for Alzheimer's Disease and Related Dementias in the U.S.
This study is looking at how lifestyle choices and surroundings can affect brain health in people aged 45 to 64, with the goal of finding ways to help prevent Alzheimer's and related memory issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10832629 on NIH RePORTER |
What this research studies
This research investigates the cognitive trajectories of individuals in middle age, specifically targeting those aged 45-64, to identify modifiable risk factors for Alzheimer's disease and related dementias (ADRD). The study aims to explore both individual health behaviors, such as alcohol consumption and chronic conditions, as well as environmental factors that may influence cognitive decline. By analyzing these factors, the research seeks to develop effective prevention strategies that could delay or prevent the onset of ADRD. Participants may be asked to provide health information and undergo assessments to better understand their cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are middle-aged adults between the ages of 45 and 64, particularly those with risk factors for cognitive decline.
Not a fit: Patients who are younger than 45 or those who do not have any risk factors for Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to strategies that significantly reduce the risk of developing Alzheimer's disease and related dementias in middle-aged adults.
How similar studies have performed: Previous research has shown that addressing mid-life risk factors can potentially prevent or delay the onset of dementia, indicating that this approach has merit.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Brown, Rebecca Tyler — University of Pennsylvania
- Study coordinator: Brown, Rebecca Tyler
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.