Understanding how microtubules in neurons affect communication and stability
Mechanistic analysis of microtubule dynamics and stability in neurons
This study is looking at how tiny structures in brain cells, called microtubules, help neurons communicate properly, which is important for a healthy brain, and it could provide helpful information for people with neurological disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10994653 on NIH RePORTER |
What this research studies
This research investigates the role of microtubules, which are essential components of the neuronal structure, in maintaining proper communication between neurons. By using a combination of genetic analysis and biophysical methods, the study aims to uncover how microtubule dynamics and stability are regulated, particularly focusing on a specific acetylation site on α-tubulin. This could help to understand the mechanisms behind synaptic growth and stability, which are crucial for healthy brain function. Patients may benefit from insights gained about microtubule dysfunction related to neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders that may involve microtubule dysfunction.
Not a fit: Patients with conditions unrelated to microtubule dynamics or those not experiencing neurological issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological disorders linked to microtubule dysfunction.
How similar studies have performed: Other research has shown promising results in understanding microtubule dynamics, suggesting that this approach may yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Wildonger, Jill C — University of California, San Diego
- Study coordinator: Wildonger, Jill C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.