Understanding how microtubules help in the separation of chromosomes during cell division
The role of microtubule dynamics in midzone driven chromosome segregation in anaphase
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-11009906
This study is looking at how tiny structures in our cells help move chromosomes during cell division, which is important for making sure new cells are healthy, and it could help improve cancer treatments in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11009906 on ClinicalTrials.gov |
What this research studies
This research investigates the role of microtubules in the process of chromosome segregation during cell division, specifically focusing on the central spindle's function during anaphase. By using advanced imaging techniques, the study aims to understand how microtubules generate forces that help move chromosomes to ensure they are accurately divided into daughter cells. The research will analyze both normal and mutant conditions to gain insights into the dynamics of microtubules and their impact on chromosome movement. This knowledge could lead to better cancer therapies by targeting the mechanisms involved in cell division.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers where chromosome segregation errors are implicated in disease progression.
Not a fit: Patients with conditions unrelated to cancer or those not experiencing issues with chromosome segregation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by enhancing our understanding of how to manipulate cell division processes.
How similar studies have performed: Other research has shown promising results in understanding microtubule dynamics and their role in cancer, indicating that this approach has potential for significant advancements.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REDEMANN, STEFANIE — UNIVERSITY OF VIRGINIA
- Study coordinator: REDEMANN, STEFANIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers