Understanding how microtubules help in chromosome separation during cell division
The role of microtubule dynamics in midzone driven chromosome segregation in anaphase
This study looks at how tiny structures in our cells help make sure that chromosomes are evenly split during cell division, which is really important for preventing problems like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11248492 on NIH RePORTER |
What this research studies
This research investigates the role of microtubules, which are essential components of the cell's structure, in the process of chromosome segregation during cell division. By examining how these microtubules interact and generate forces, the study aims to uncover the mechanisms that ensure chromosomes are accurately divided into daughter cells. The research utilizes advanced imaging techniques to analyze microtubule dynamics in both normal and altered conditions, providing insights into their function during anaphase. This could lead to a better understanding of errors in cell division that can result in diseases such as cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that may be influenced by errors in cell division.
Not a fit: Patients with conditions unrelated to cell division or chromosome segregation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies by targeting the mechanisms involved in chromosome segregation.
How similar studies have performed: Previous research has shown that understanding microtubule dynamics can lead to significant advancements in cancer treatment, indicating a promising avenue for this study.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Redemann, Stefanie — University of Virginia
- Study coordinator: Redemann, Stefanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.