Understanding how microtubules function during cell division
Gardner Lab MIRA Proposal: Microtubules and Mitosis
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-11053478
This study is looking at how tiny structures in our cells help them divide properly, which is really important for keeping our genes safe and preventing cancer, and it's for anyone interested in understanding how our cells work.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11053478 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that regulate microtubule lengths and the forces involved in chromosome segregation during cell division. By combining experimental techniques with computational modeling, the team aims to uncover how changes at the molecular level can impact cellular processes. The findings could lead to new insights into how cells maintain genome integrity during mitosis, which is crucial for preventing cancer. The research focuses on the interactions between microtubules and proteins, as well as the signaling mechanisms that guide these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that involve disruptions in cell division and microtubule dynamics.
Not a fit: Patients with non-cancerous conditions or those whose cancers are not related to microtubule dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved anti-cancer therapies by enhancing our understanding of cell division and its regulation.
How similar studies have performed: Other research has shown success in understanding microtubule dynamics and their role in cancer, indicating that this approach is built on a foundation of prior findings.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARDNER, MELISSA — UNIVERSITY OF MINNESOTA
- Study coordinator: GARDNER, MELISSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, cancer cell