Understanding how microtubules form during cell division
Role and Mechanisms of Microtubule Nucleation in Spindle Assembly
This study is looking at how tiny structures in our cells help them divide properly, which is really important for keeping our bodies healthy, and it could help us understand more about cancer and other diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project ID | NIH-11010010 on NIH RePORTER |
What this research studies
This research investigates the process of microtubule nucleation, which is crucial for the assembly of the mitotic spindle during cell division. By using advanced techniques to visualize microtubule formation in a controlled environment, the researchers aim to uncover the timing and location of microtubule assembly near chromosomes. The study will explore the roles of specific proteins and pathways that facilitate this process, providing insights into how cells ensure accurate chromosome segregation. This knowledge could lead to a better understanding of cell division and its implications in cancer and other diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers where cell division plays a critical role in disease progression.
Not a fit: Patients with non-cancerous conditions or those not affected by issues related to cell division may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cell division in cancer therapies.
How similar studies have performed: Other research has shown promising results in understanding microtubule dynamics, making this approach a continuation of established findings in the field.
Where this research is happening
Princeton, UNITED STATES
- Princeton University — Princeton, United States (Active)
Researchers
- Principal investigator: Petry, Sabine — Princeton University
- Study coordinator: Petry, Sabine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.