Understanding how microtubules behave in healthy and injured neurons
Pairing Modeling and Experiment to Understand Microtubule Behavior in Healthy and Injured Neurons
This study is looking at how tiny structures in nerve cells, called microtubules, behave when the cells get hurt, and it aims to help us understand how these structures can help nerves heal and recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-11118792 on NIH RePORTER |
What this research studies
This research investigates the behavior of microtubules, which are essential for neuron function, particularly in the context of injury. By developing a mathematical model that simulates the organization and dynamics of microtubules in neurons, the research aims to understand how these structures respond to damage. The approach combines computational modeling with experimental validation to explore the mechanisms that control microtubule stability and polarity. This knowledge could lead to insights into neuronal resilience and recovery after injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with acute axonal injuries or conditions affecting neuronal function.
Not a fit: Patients with chronic neurological conditions unrelated to axonal injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of neuronal repair mechanisms, potentially leading to improved treatments for nerve injuries.
How similar studies have performed: Other research has shown promise in using computational models to understand cellular behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Rolls, Melissa — Pennsylvania State University, the
- Study coordinator: Rolls, Melissa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.