Understanding how microtubules affect cell structure and function in health and disease
Defining microtubule cytoskeleton regulatory pathways in development and disease
This study is looking at how tiny structures in our cells, called microtubules, work and how they can go wrong, which might help us understand and treat conditions like neurodevelopmental disorders and cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10841272 on NIH RePORTER |
What this research studies
This research investigates the regulatory pathways of microtubules, which are essential components of the cell's cytoskeleton. By examining how microtubule-associated proteins (MAPs) interact with microtubules, the study aims to uncover the mechanisms that govern cellular architecture and function. The research employs various biochemical assays and cellular models to analyze how disruptions in these pathways can lead to diseases such as neurodevelopmental disorders and cancers. Patients may benefit from insights gained about how to restore normal cellular function and potentially develop targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurodevelopmental disorders, neurodegenerative diseases, or certain types of cancers.
Not a fit: Patients with conditions unrelated to cytoskeletal dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to cytoskeletal dysfunction, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of microtubules in cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Ori-Mckenney, Kassandra Marie — University of California at Davis
- Study coordinator: Ori-Mckenney, Kassandra Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.