Understanding how microtubule structures help cells divide accurately
Microtubule bundles in the mitotic spindle: probing how mechanical and functional robustness emerge from molecular architecture
This study is looking at how a special part of our cells, called the mitotic spindle, helps make sure that chromosomes are divided correctly during cell division, which is important for keeping us healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project ID | NIH-10914848 on NIH RePORTER |
What this research studies
This research investigates the mitotic spindle, a crucial structure that ensures chromosomes are accurately separated during cell division. By examining the mechanical and biochemical properties of microtubule bundles, the research aims to uncover how these structures maintain their function and integrity. The study employs a multi-system approach, analyzing spindle mechanics in both mammalian cells and fission yeast, as well as in controlled laboratory conditions. This comprehensive methodology seeks to provide insights into the fundamental processes that prevent errors in chromosome segregation, which can lead to serious health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by conditions related to chromosome segregation errors, including certain cancers and congenital abnormalities.
Not a fit: Patients with conditions unrelated to chromosome segregation or those not experiencing any genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for conditions related to chromosome segregation errors, such as certain cancers and congenital defects.
How similar studies have performed: Other research has shown success in understanding microtubule mechanics and their role in cell division, indicating that this approach is built on established scientific principles.
Where this research is happening
Raleigh, United States
- North Carolina State University Raleigh — Raleigh, United States (Active)
Researchers
- Principal investigator: Elting, Mary Williard — North Carolina State University Raleigh
- Study coordinator: Elting, Mary Williard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.