Understanding how microtubule networks work during cell division
Official title: Deciphering the mechanics of microtubule networks in mitosis
Funded at Rensselaer Polytechnic Institute · NIH-11058452 · Data updated 2026-11-12
This study is looking at how tiny structures in our cells help make sure chromosomes are divided correctly during cell division, which could lead to better treatments for conditions caused by mistakes in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rensselaer Polytechnic Institute NIH-funded |
| Lab location | 1 site (Troy, United States) |
| Project start | May 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $321,139 |
| NIH project number | 5R01GM149782-03 |
| Project ID | NIH-11058452 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with neurodegenerative diseases, particularly those related to Alzheimer's disease.
✕Less likely to help
Patients with conditions unrelated to cell division or neurodegenerative diseases may not receive any benefit from this research.
What this research studies
This research investigates the mechanics of microtubule networks, which are crucial for the proper segregation of chromosomes during cell division. By using advanced techniques such as single-molecule fluorescence microscopy and live-cell imaging, the team aims to uncover the molecular mechanisms that govern the assembly and function of these networks. The study focuses on specific proteins that play a role in organizing these networks, particularly during the different phases of mitosis. Patients may benefit from insights gained into cellular processes that could inform future treatments for conditions related to cell division errors.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with cell division errors, including certain neurodegenerative conditions.
How similar studies have gone: While the specific focus on microtubule networks in mitosis is a novel approach, related research in cell division mechanics has shown promising results in understanding cellular processes.
Where this research is happening
-
Rensselaer Polytechnic Institute
Troy, United States Active
Researchers
- Principal investigator: Forth, Scott Thomas — Rensselaer Polytechnic Institute
- Study coordinator: Forth, Scott Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.