Understanding how microtubule inner proteins function in cilia and basal bodies
MIPS (Microtubule Inner Proteins) function in cilia and basal bodies
This study looks at special proteins that help keep tiny structures in our cells, called microtubules, strong and working well, which is important for things like moving fluids in the body and supporting nerve cells, and the findings could help people with conditions caused by problems in these structures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11049012 on NIH RePORTER |
What this research studies
This research investigates the role of microtubule inner proteins (MIPs) in the assembly and maintenance of stable microtubules, which are crucial for cellular functions such as axonal transport and ciliary movement. By examining how these proteins interact with microtubules, the study aims to uncover the mechanisms that allow cilia to effectively move fluids in the body. The research employs advanced biophysical techniques to analyze the structure and function of these proteins in various cellular contexts, particularly in neurons and cilia. Patients may benefit from insights gained about microtubule function in conditions related to ciliary dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include adolescents with myoclonic epilepsy or other conditions linked to ciliary dysfunction.
Not a fit: Patients with conditions unrelated to ciliary function or microtubule stability may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for conditions associated with ciliary dysfunction, such as certain types of epilepsy.
How similar studies have performed: Previous research has shown promising results in understanding microtubule dynamics and their associated proteins, suggesting that this approach could yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Winey, Mark — University of California at Davis
- Study coordinator: Winey, Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.