Understanding how microsporidia parasites invade host cells
Structural basis of the polar tube invasion machinery from microsporidia parasites
This study is looking at how a tiny fungus called microsporidia gets into cells, especially in people with weakened immune systems, to help find better ways to treat infections caused by it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11076988 on NIH RePORTER |
What this research studies
This research investigates the unique mechanism by which microsporidia, a type of fungal parasite, invade host cells. It focuses on the polar tube, a specialized structure that microsporidia use to penetrate and infect cells, particularly in immunocompromised individuals. By employing advanced techniques like cryo-electron microscopy and various biochemical methods, the research aims to uncover the molecular details of this invasion process. This knowledge could lead to better understanding and treatment options for infections caused by these parasites.
Who could benefit from this research
Good fit: Ideal candidates for this research are immunocompromised individuals, such as those living with HIV/AIDS or undergoing immunosuppressive therapies.
Not a fit: Patients with strong immune systems or those not affected by microsporidia infections are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for microsporidiosis, particularly in patients with weakened immune systems.
How similar studies have performed: Previous research has shown promise in understanding similar parasitic invasion mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Bhabha, Gira — Johns Hopkins University
- Study coordinator: Bhabha, Gira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.