Understanding how microRNAs influence fentanyl addiction
Official title: Delineation of microRNA regulatory pathways that support fentanyl-seeking behavior
Funded at Temple Univ of the Commonwealth · NIH-11052662 · Data updated 2026-11-12
This study is looking at how tiny molecules in the brain, called microRNAs, affect how our bodies respond to fentanyl, a strong opioid that can lead to addiction, and it aims to find markers in blood that might help identify people at risk of developing a fentanyl addiction, which could lead to better treatments for those who need help.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $198,124 |
| NIH project number | 5R21DA058121-02 |
| Project ID | NIH-11052662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of fentanyl use or those at risk of opioid addiction.
✕Less likely to help
Patients who have not been exposed to opioids or who are not struggling with addiction may not benefit from this research.
What this research studies
This research investigates the role of microRNAs in the brain's response to fentanyl, a powerful opioid that has contributed to a significant increase in overdose deaths. By examining how these microRNAs regulate gene expression and influence addictive behaviors, the study aims to uncover the unique neuroadaptations caused by fentanyl compared to other opioids. The research will analyze blood samples to identify biomarkers that could indicate a person's risk of developing fentanyl-seeking behavior. This approach may help in developing targeted treatments for those struggling with fentanyl addiction.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers and treatment strategies for individuals affected by fentanyl addiction.
How similar studies have gone: Previous research has shown that microRNAs play a significant role in addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Daws, Stephanie — Temple Univ of the Commonwealth
- Study coordinator: Daws, Stephanie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.