Understanding how microRNAs control animal development
Roles of microRNAs in animal development
This study looks at how tiny molecules called microRNAs help control gene activity as cells grow into complex organisms, using a small worm as a model, and it aims to understand how changes in these molecules might be connected to certain human diseases, including some that cause hearing loss.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11010250 on NIH RePORTER |
What this research studies
This research investigates the role of microRNAs in regulating gene expression during the development of multicellular organisms from a single cell. By studying the mechanisms of post-transcriptional repression, the research aims to uncover how these small RNA molecules influence protein production at different stages of development. The approach involves using model organisms like C. elegans to explore the effects of microRNA mutations and their links to human diseases, including syndromic conditions and progressive deafness. The findings could provide insights into fundamental biological processes and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders related to microRNA mutations, particularly those experiencing developmental issues or hearing loss.
Not a fit: Patients with conditions unrelated to microRNA function or those not experiencing developmental or genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental disorders and new strategies for treating genetic diseases linked to microRNA dysfunction.
How similar studies have performed: Previous research has shown success in understanding the roles of microRNAs in development and disease, indicating that this approach is grounded in established scientific principles.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Cochella, Luisa — Johns Hopkins University
- Study coordinator: Cochella, Luisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.