Understanding how microRNAs are regulated in various diseases
Molecular mechanisms for regulating microRNA levels in metazoans
['FUNDING_OTHER'] · UNIVERSITY OF FLORIDA · NIH-10909826
This study is looking at tiny molecules called microRNAs that help control how our genes work, especially in diseases like cancer and brain disorders, to find out what affects their levels and how this knowledge could lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10909826 on ClinicalTrials.gov |
What this research studies
This research investigates the role of microRNAs (miRNAs) in gene expression and how their levels are regulated in diseases such as cancer and neurodegenerative disorders. By exploring mechanisms like target-directed miRNA degradation (TDMD) and the function of the enzyme Dicer, the research aims to identify triggers that affect miRNA abundance. The approach includes using advanced biochemical techniques and bioinformatics to analyze miRNA interactions in cultured cells and model organisms. Patients may benefit from insights that could lead to new therapeutic strategies targeting miRNA regulation.
Who could benefit from this research
Good fit: Ideal candidates include individuals with cancers, developmental defects, or neurodegenerative diseases linked to miRNA dysregulation.
Not a fit: Patients with conditions unrelated to miRNA regulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases associated with dysregulated miRNA levels.
How similar studies have performed: Previous research has shown promising results in understanding miRNA roles in various diseases, indicating that this approach has potential for success.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIE, MINGYI — UNIVERSITY OF FLORIDA
- Study coordinator: XIE, MINGYI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers