Understanding how microRNAs affect neutrophilic asthma
Systems Biology of a MicroRNA Network in Neutrophilic Asthma
This study is looking at how a tiny molecule called miR-223-3p affects neutrophilic asthma, which is a type of asthma that causes inflammation from a certain type of white blood cell, and it's especially for people who don't get better with regular asthma medications; by examining samples from patients, researchers hope to find new ways to help manage this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10860994 on NIH RePORTER |
What this research studies
This research investigates the role of microRNAs, specifically miR-223-3p, in neutrophilic asthma, a type of asthma characterized by inflammation from neutrophils rather than eosinophils. The study aims to uncover how these microRNAs influence airway inflammation and asthma severity, particularly in patients who do not respond well to standard corticosteroid treatments. By analyzing sputum samples from patients, researchers will identify the specific pathways and cellular interactions involved in this condition, potentially leading to new therapeutic targets. The approach includes advanced techniques like in situ hybridization to visualize the expression of miRNAs in sputum cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with neutrophilic asthma who have not responded adequately to corticosteroid therapies.
Not a fit: Patients with eosinophilic asthma or those whose asthma is well-controlled with current treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with neutrophilic asthma, particularly those who currently have limited options.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in asthma, but the specific focus on neutrophilic asthma and miR-223-3p is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Gomez-Villalobos, Jose Luis — Yale University
- Study coordinator: Gomez-Villalobos, Jose Luis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.