Understanding how microRNAs affect addiction to stimulants and opioids
Micro-RNAs in Stimulant and Opioid Action
This study is looking at how tiny molecules in the brain, called microRNAs, affect how our brains respond to drugs like stimulants and opioids, which could help us understand addiction better and find new ways to treat it.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10934811 on NIH RePORTER |
What this research studies
This research investigates the role of specific microRNAs, particularly miR-132 and miR-212, in the brain's response to stimulant and opioid drugs. By studying how these microRNAs are regulated by microglia and the cytokine TNFα, the research aims to uncover mechanisms that influence drug-seeking behavior and addiction. The approach involves examining brain regions associated with addiction, such as the nucleus accumbens, and assessing how changes in microRNA signaling can affect neuronal plasticity and behavior. Patients may benefit from insights that could lead to new treatment strategies for addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with stimulant or opioid addiction.
Not a fit: Patients who are not currently experiencing addiction or are not using stimulants or opioids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic approaches for treating addiction to stimulants and opioids.
How similar studies have performed: Previous research has shown promising results in understanding the role of microRNAs in addiction, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Kenny, Paul J. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Kenny, Paul J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.