Understanding how microRNA decay affects blood cell development
Official title: Mechanisms and relevance of miRNA decay during hematopoietic development
Funded at Washington University · NIH-10941648 · Data updated 2026-11-12
This study is looking at how tiny molecules called microRNAs affect the way our blood cells are made, especially when certain genes are changed, and it hopes to help people with blood disorders like bone marrow failure by finding out more about these processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $657,368 |
| NIH project number | 1R01HL174789-01 |
| Project ID | NIH-10941648 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic mutations affecting blood cell development or those diagnosed with blood disorders.
✕Less likely to help
Patients with unrelated health conditions or those not affected by blood cell development issues may not receive any benefit from this research.
What this research studies
This research investigates the role of microRNAs (miRNAs) in the development of blood cells, focusing on how their degradation impacts hematopoiesis. By studying human pluripotent stem cells with specific genetic mutations, the research aims to uncover the molecular pathways that regulate miRNA processing and degradation. This could lead to a better understanding of blood cell formation and the underlying mechanisms of related disorders. Patients may benefit from insights gained into conditions like bone marrow failure syndromes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood disorders caused by miRNA dysregulation.
How similar studies have gone: Previous research has shown that understanding miRNA functions can lead to significant advancements in treating blood-related conditions, indicating a promising avenue for this investigation.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Batista, Luis Francisco Zirnberger — Washington University
- Study coordinator: Batista, Luis Francisco Zirnberger
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.